Antenatal management of fetal and neonatal alloimmune thrombocytopenia: Integration of clinical history and maternal HLA-DRB3*01:01 genotyping in clinical decision-making.

Abstract excerpt

BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare but potentially life-threatening condition caused by maternal alloantibodies against paternally inherited fetal human platelet antigens (HPA), most commonly HPA-1a. The condition may result in severe thrombocytopenia, with the most serious complication being intracranial hemorrhage (ICH). Effective risk stratification and antenatal...

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