Article
Alloantibodies against low-frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases.
Transfusion - 1 Oct 2009
Ghevaert Cedric, Rankin Angela, Huiskes Elly, Porcelijn Leendert, Javela Kaija, Kekomaki Riitta, Bakchoul Tamam, Santoso Sentot, Nutland Sarah, Smyth Deborah J, Smith Graham A, McBride Simon, Watkins Nicholas A, Ouwehand Willem H
Abstract excerpt
BACKGROUND: Maternal alloantibodies against the five common human platelet antigen (HPA) systems (HPA-1 to -3, -5, and -15) are found in only 20% of cases referred for fetal and neonatal thrombocytopenia (FMAIT) investigations. The question asked was whether mismatches for the remaining 11 low-frequency HPAs (HPA-4 and -6bw to -17bw) might in part explain the remaining 80% of cases. STUDY DESIGN AND METHODS: A...
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