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Article

Epigenetic regulation by the menin pathway

15 Aug 2017

Abstract excerpt

There is a trend of increasing prevalence of neuroendocrine tumors (NETs), and the inherited multiple endocrine neoplasia type 1 (MEN1) syndrome serves as a genetic model to investigate how NETs develop and the underlying mechanisms. Menin, encoded by the MEN1 gene, at least partly acts as a scaffold protein by interacting with multiple partners to regulate cellular homeostasis of various endocrine organs. Menin...

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PMID: 28811300
DOI: 10.1530/erc-17-0298

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