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Article

Proteomic and phosphoproteomic analyses of myectomy tissue reveals difference between sarcomeric and genotype-negative hypertrophic cardiomyopathy.

Scientific reports - 1 Sept 2023

Garmany Ramin, Bos J Martijn, Dasari Surendra, Johnson Kenneth L, Tester David J, Giudicessi John R, Dos Remedios Cristobal, Maleszewski Joseph J, Ommen Steve R, Dearani Joseph A, Ackerman Michael J

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a genetically heterogenous condition with about half of cases remaining genetically elusive or non-genetic in origin. HCM patients with a positive genetic test (HCMSarc) present earlier and with more severe disease than those with a negative genetic test (HCMNeg). We hypothesized these differences may be due to and/or reflect proteomic and phosphoproteomic differences between...

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Identifiers

PMID: 37658118
DOI: 10.1038/s41598-023-40795-1
PMCID: PMC10474105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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