Article

Atrial Proteomic Profiling Reveals a Switch Towards Profibrotic Gene Expression Program in CREM-IbΔC-X Mice with Persistent Atrial Fibrillation

2024-01-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Overexpression of the CREM (cAMP response element-binding modulator) isoform CREM-IbΔC-X in transgenic mice (CREM-Tg) causes the age-dependent development of spontaneous AF. <h4>Purpose</h4> To identify key proteome signatures and biological processes accompanying the development of persistent AF through integrated proteomics and bioinformatics analysis. <h4>Methods</h4> A...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6aabee0-40bd-50fc-9402-9f9f8271afaf
DOI: 10.1101/2024.01.10.575097

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Atrial Proteomic Profiling Reveals a Switch Towards Profibrotic Gene Expression Program in CREM-IbΔC-X Mice with Persistent Atrial FibrillationDOI 10.1101/2024.01.10.575097Read

Inward Rectifier K+ Currents Contribute to the Proarrhythmic Electrical Phenotype of Atria Overexpressing Cyclic Adenosine Monophosphate Response Element Modulator Isoform CREM-IbΔC-X.Semantic proximity Read

Transcriptome and proteome mapping in the sheep atria reveal molecular featurets of atrial fibrillation progressionSemantic proximity Read

Compartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillationSemantic proximity Read

Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.Semantic proximity Read

ERBB4 deficiency promotes atrial myopathy underlying the atrial fibrillation substrateSemantic proximity Read

LKB1 knockout mouse develops spontaneous atrial fibrillation and provides mechanistic insights into human disease process.Semantic proximity Read

Systematic Analysis of Gene Expression Differences between Left and Right Atria in Different Mouse Strains and in Human Atrial TissueSemantic proximity Read

Transcriptome analysis reveals key pathways that vary in patients with paroxysmal and persistent atrial fibrillationSemantic proximity Read

Genome-wide transcript and protein analysis reveals distinct features of aging in the mouse heartSemantic proximity Read

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.Semantic proximity Read

Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del-Related Cardiomyopathy.Semantic proximity Read

Longitudinal Plasma Proteome Changes Before and After Catheter Ablation in Atrial FibrillationSemantic proximity Read