TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.

doi:10.1093/cvr/cvw218

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Article

TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.

Cardiovascular research - 1 Jan 2017

Rogers Natasha M, Sharifi-Sanjani Maryam, Yao Mingyi, Ghimire Kedar, Bienes-Martinez Raquel, Mutchler Stephanie M, Knupp Heather E, Baust Jeffrey, Novelli Enrico M, Ross Mark, St Croix Claudette, Kutten Johannes C, Czajka Caitlin A, Sembrat John C, Rojas Mauricio, Labrousse-Arias David, Bachman Timothy N, Vanderpool Rebecca R, Zuckerbraun Brian S, Champion Hunter C, Mora Ana L, Straub Adam C, Bilonick Richard A, Calzada Maria J, Isenberg Jeffrey S

Abstract excerpt

AIMS: Thrombospondin-1 (TSP1) is a ligand for CD47 and TSP1-/- mice are protected from pulmonary hypertension (PH). We hypothesized the TSP1-CD47 axis is upregulated in human PH and promotes pulmonary arterial vasculopathy. METHODS AND RESULTS: We analyzed the molecular signature and functional response of lung tissue and distal pulmonary arteries (PAs) from individuals with (n = 23) and without (n = 16) PH....

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Identifiers

PMID: 27742621
DOI: 10.1093/cvr/cvw218
PMCID: PMC5220673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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