Article
Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Leukemia - 1 Apr 2017
Uy G L, Duncavage E J, Chang G S, Jacoby M A, Miller C A, Shao J, Heath S, Elliott K, Reineck T, Fulton R S, Fronick C C, O'Laughlin M, Ganel L, Abboud C N, Cashen A F, DiPersio J F, Wilson R K, Link D C, Welch J S, Ley T J, Graubert T A, Westervelt P, Walter M J
Abstract excerpt
Traditional response criteria in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are based on bone marrow morphology and may not accurately reflect clonal tumor burden in patients treated with non-cytotoxic chemotherapy. We used next-generation sequencing of serial bone marrow samples to monitor MDS and AML tumor burden during treatment with epigenetic therapy (decitabine and panobinostat). Serial...
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