Article

High-fat diet-induced obesity increases susceptibility to endogenous and ethyl carbamate-induced somatic mutagenesis

2023-06-14

Abstract excerpt

Obesity and dietary fat consumption are associated with increased risk for certain cancers. We conducted a set of experiments designed to investigate both the inherent mutagenicity of high-fat diet (HFD) and the effect of HFD exposure on sensitivity to ethyl carbamate, a known mutagen. Greater body mass in females was associated with higher frequency of Pig-a mutant erythrocytes and HFD-induced obese female mice e...

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Literature Corpus work: 377015d9-42fc-59ad-af8f-7ff7c8a7db3f
DOI: 10.1101/2023.06.14.543760

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