Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the γ‐H2AX focus assay and micronucleus test

Abstract excerpt

Childhood obesity, often characterized by a chronic low-grade inflammation, has been associated with an increased risk of developing some types of cancer later in life. Nuclear γ-H2AX foci represent the first detectable response of cells to DNA tumorigenesis lesions, such as the double-strand breaks (DSBs). An excess of micronucleated peripheral lymphocytes was found in subjects with cancer or inflammation-based...

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