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Article

A multi-SNP locus-association method reveals a substantial fraction of the missing heritability.

American journal of human genetics - 2 Nov 2012

Ehret Georg B, Lamparter David, Hoggart Clive J, Whittaker John C, Beckmann Jacques S, Kutalik Zoltán

Abstract excerpt

There are many known examples of multiple semi-independent associations at individual loci; such associations might arise either because of true allelic heterogeneity or because of imperfect tagging of an unobserved causal variant. This phenomenon is of great importance in monogenic traits but has not yet been systematically investigated and quantified in complex-trait genome-wide association studies (GWASs)....

Read the complete abstract on PubMed

Topics

Body Mass Index
Genome-Wide Association Study
Humans
Lipids
Phenotype
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

Waist-Hip Ratio

Source

Open in PubMed Open full text

Identifiers

PMID: 23122585
DOI: 10.1016/j.ajhg.2012.09.013
PMCID: PMC3487134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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