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Article

Fluorescent Trimethoprim Conjugate Probes To Assess Drug Accumulation in Wild Type and Mutant Escherichia coli.

ACS infectious diseases - 14 Oct 2016

Phetsang Wanida, Pelingon Ruby, Butler Mark S, Kc Sanjaya, Pitt Miranda E, Kaeslin Geraldine, Cooper Matthew A, Blaskovich Mark A T

Abstract excerpt

Reduced susceptibility to antimicrobials in Gram-negative bacteria may result from multiple resistance mechanisms, including increased efflux pump activity or reduced porin protein expression. Up-regulation of the efflux pump system is closely associated with multidrug resistance (MDR). To help investigate the role of efflux pumps on compound accumulation, a fluorescence-based assay was developed using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27737551
DOI: 10.1021/acsinfecdis.6b00080
PMCID: PMC5067704

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DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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