Article

The Quantification of Drug Accumulation within Gram-Negative Bacteria

2025-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Intrabacterial drug accumulation, mediated by the bacterial permeability barrier, efflux, and intrabacterial drug metabolism, is of general significance to the interaction between small molecules and bacteria. For example, the ability of a small molecule to accumulate within a bacterium influences its ability to serve as a chemical probe of an intracellular protein target and/or its efficacy as...

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Literature Corpus work: a2b7a66e-6019-5522-ba9e-d6e4add03f70
DOI: 10.1101/2025.05.28.656715

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