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Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria

12 Apr 2017

Abstract excerpt

A main challenge in chemotherapy is to determine the in cellulo parameters modulating the drug concentration required for therapeutic action. It is absolutely urgent to understand membrane permeation and intracellular concentration of antibiotics in clinical isolates: passing the membrane barrier to reach the threshold concentration inside the bacterial periplasm or cytoplasm is the pivotal step of antibacterial...

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Share to Antibiotic Resistance in Bacteria
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PMID: 28428543
DOI: 10.1038/s41598-017-00945-8

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