Ratiometric Fluorescence Detection of Pathogenic Bacteria Resistant to Broad‐Spectrum β‐Lactam Antibiotics

Abstract excerpt

Identification of bacteria: A methoxyimino cephalosporin derivative containing a pair of fluorescence resonance energy transfer (FRET) fluorophores was synthesized. This probe displays selective cleavage toward different types of β-lactamases, thereby providing a rapid assay to distinguish bacterial cells that are either sensitive or resistant to broad-spectrum β-lactam antibiotics (see picture).

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