Article

Monitoring intracellular antibiotic concentrations in real-time using allosteric biosensors

2026-02-05

Abstract excerpt

Antibiotic treatment can fail due to insufficient drug availability at the site of infection or limited accumulation within bacterial pathogens. However, it is poorly understood how antibiotics penetrate infected tissues and complex bacterial aggregates, limiting insights into the mechanisms of treatment failure. Here, we present genetically-encoded allosteric biosensors for two antibiotic classes, trimethoprim an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 12e02f32-03a9-5b82-8f2d-3d4f4aceceef
DOI: 10.64898/2026.02.05.704027

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Monitoring intracellular antibiotic concentrations in real-time using allosteric biosensorsDOI 10.64898/2026.02.05.704027Read

Rapid Antibiotic Susceptibility Testing of Uropathogenic E. coli by Tracking Submicron Scale Motion of Single Bacterial CellsSemantic proximity Read

Antibiotic susceptibility testing in less than 30 min using direct single-cell imagingSemantic proximity Read

Antimicrobial Susceptibility Test with Plasmonic Imaging and Tracking of Single Bacterial Motions on Nanometer ScaleSemantic proximity Read

Rapid electrochemical phenotypic profiling of antibiotic-resistant bacteria.Semantic proximity Read

Detection of Quorum-Sensing Molecules for Pathogenic Molecules Using Cell-Based and Cell-Free BiosensorsSemantic proximity Read

Single-cell microfluidics enabled dynamic evaluation of drug combinations on antibiotic resistance bacteriaSemantic proximity Read

Bacterial Nanoscale Cultures for Phenotypic Multiplexed Antibiotic Susceptibility TestingSemantic proximity Read

Electrochemical Biosensing for Antibiotic-Resistant Bacteria: Advances, Challenges, and Future DirectionsSemantic proximity Read

Novel Method for the Rapid Establishment of Antibiotic Susceptibility Profiles in Bacterial Strains Linked to Musculoskeletal Infections Using Scattered Light Integrated Collector TechnologySemantic proximity Read

Novel CRISPR-Cas13 Biosensor for Real-Time Detection of Antimicrobial Resistance Genes in Environmental MicrobiomesSemantic proximity Read

Novel CRISPR-Cas13 Biosensor for Real-Time Detection of Antimicrobial Resistance Genes in Environmental MicrobiomesSemantic proximity Read

A cell-free strategy for profiling of intracellular antibiotic sensitivity and resistanceSemantic proximity Read