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Article

Porcine Zygote Injection with Cas9/sgRNA Results in DMD-Modified Pig with Muscle Dystrophy.

International journal of molecular sciences - 9 Oct 2016

Yu Hong-Hao, Zhao Heng, Qing Yu-Bo, Pan Wei-Rong, Jia Bao-Yu, Zhao Hong-Ye, Huang Xing-Xu, Wei Hong-Jiang

Abstract excerpt

Dystrophinopathy, including Duchenne muscle dystrophy (DMD) and Becker muscle dystrophy (BMD) is an incurable X-linked hereditary muscle dystrophy caused by a mutation in the DMD gene in coding dystrophin. Advances in further understanding DMD/BMD for therapy are expected. Studies on mdx mice and dogs with muscle dystrophy provide limited insight into DMD disease mechanisms and therapeutic testing because of the...

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Identifiers

PMID: 27735844
DOI: 10.3390/ijms17101668
PMCID: PMC5085701

Genes

DMD

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