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Article

A novel rabbit model of Duchenne muscular dystrophy generated by CRISPR/Cas9.

Disease models & mechanisms - 4 Jun 2018

Sui Tingting, Lau Yeh Siang, Liu Di, Liu Tingjun, Xu Li, Gao Yandi, Lai Liangxue, Li Zhanjun, Han Renzhi

Abstract excerpt

Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disorder caused by mutations in the dystrophin gene, with an incidence of 1 in 3500 in new male births. Mdx mice are widely used as an animal model for DMD. However, these mice do not faithfully recapitulate DMD patients in many aspects, rendering the preclinical findings in this model questionable. Although larger animal models of DMD, such as dogs...

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Identifiers

PMID: 29871865
DOI: 10.1242/dmm.032201
PMCID: PMC6031364

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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