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Article

A scalable, clinically severe pig model for Duchenne muscular dystrophy

19 Nov 2021

Abstract excerpt

Large-animal models for Duchenne muscular dystrophy (DMD) are crucial for the evaluation of diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 (DMDΔ52) exhibit molecular, clinical and pathological hallmarks of DMD, but die before sexual maturity and cannot be propagated by breeding. Therefore, we generated female DMD+/- carriers. A single founder animal had 11 litters...

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PMID: 34796900
DOI: 10.1242/dmm.049285

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