Article
Generation of muscular dystrophy model rats with a CRISPR/Cas system.
Scientific reports - 9 Jul 2014
Nakamura Katsuyuki, Fujii Wataru, Tsuboi Masaya, Tanihata Jun, Teramoto Naomi, Takeuchi Shiho, Naito Kunihiko, Yamanouchi Keitaro, Nishihara Masugi
Abstract excerpt
Duchenne muscular dystrophy (DMD) is an X-linked lethal muscle disorder caused by mutations in the Dmd gene encoding Dystrophin. DMD model animals, such as mdx mice and canine X-linked muscular dystrophy dogs, have been widely utilized in the development of a treatment for DMD. Here, we demonstrate the generation of Dmd-mutated rats using a clustered interspaced short palindromic repeats (CRISPR)/Cas system, an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.