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Article

Angiotensin I-converting enzyme mutation (Trp1197Stop) causes a dramatic increase in blood ACE.

PloS one - 14 Dec 2009

Nesterovitch Andrew B, Hogarth Kyle D, Adarichev Vyacheslav A, Vinokour Elena I, Schwartz David E, Solway Julian, Danilov Sergei M

Abstract excerpt

BACKGROUND: Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling. Elevated ACE levels may be associated with an increased risk for different cardiovascular or respiratory diseases, including asthma. Previously, a molecular mechanism underlying a 5-fold familial increase of blood ACE was discovered: Pro1199Leu substitution enhanced...

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Identifiers

PMID: 20011602
DOI: 10.1371/journal.pone.0008282
PMCID: PMC2788243

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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