Article
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma.
Blood - 5 Jan 2017
Du Jing, Neuenschwander Martin, Yu Yong, Däbritz J Henry M, Neuendorff Nina-Rosa, Schleich Kolja, Bittner Aitomi, Milanovic Maja, Beuster Gregor, Radetzki Silke, Specker Edgar, Reimann Maurice, Rosenbauer Frank, Mathas Stephan, Lohneis Philipp, Hummel Michael, Dörken Bernd, von Kries Jens Peter, Lee Soyoung, Schmitt Clemens A
Abstract excerpt
Classical Hodgkin lymphoma (cHL), although originating from B cells, is characterized by the virtual lack of gene products whose expression constitutes the B-cell phenotype. Epigenetic repression of B-cell-specific genes via promoter hypermethylation and histone deacetylation as well as compromised expression of B-cell-committed transcription factors were previously reported to contribute to the lost B-cell...
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