Article

<i>RHOA</i> Deletion Downregulates CD19 and Promotes Dysfunctional Immune Microenvironments in CAR-T Resistant B-Cell Lymphoma

2025-03-04

Abstract excerpt

<h4>ABSTRACT</h4> CD19-directed chimeric antigen receptor (CAR)-T cells are breakthrough therapies for aggressive B-cell lymphomas, but less than half of patients achieve durable responses. We previously showed through whole-genome sequencing of tumors from CAR-T-treated patients that deletions of RHOA (3p21.31) are enriched in cases progressing after treatment. RHOA ’s roles in resistance and pathogenesis are...

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Literature Corpus work: 7e370b0b-07a5-5c5f-88fa-56d614678cb0
DOI: 10.1101/2025.02.27.640687

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