Article
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Nature immunology - 1 Feb 2006
Mathas Stephan, Janz Martin, Hummel Franziska, Hummel Michael, Wollert-Wulf Brigitte, Lusatis Simone, Anagnostopoulos Ioannis, Lietz Andreas, Sigvardsson Mikael, Jundt Franziska, Jöhrens Korinna, Bommert Kurt, Stein Harald, Dörken Bernd
Abstract excerpt
B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell-specific transcription factor...
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