Article
Histone acetylation and DNA demethylation of B cells result in a Hodgkin-like phenotype.
Leukemia - 1 Apr 2008
Ehlers A, Oker E, Bentink S, Lenze D, Stein H, Hummel M
Abstract excerpt
A unique feature of the tumor cells (Hodgkin/Reed-Sternberg (HRS)) of classical Hodgkin lymphoma (cHL) is the loss of their B-cell phenotype despite their B-cell origin. Several lines of evidence suggest that epigenomic events, especially promoter DNA methylation, are involved in this silencing of many B-cell-associated genes. Here, we show that DNA demethylation alone or in conjunction with histone acetylation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.