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Article

Reprogramming of the tumour B-cell phenotype in Hodgkin lymphoma.

Trends in immunology - 1 May 2006

Küppers Ralf, Bräuninger Andreas

Abstract excerpt

Hodgkin and Reed-Sternberg (HRS) cells, the tumour cells in classical Hodgkin lymphoma, derive from mature B cells but have largely lost their B-cell phenotype. This extensive reprogramming is unique among B-cell lymphomas. A recent study by Dörken and colleagues provides an interesting insight into the mechanisms for this reprogramming by demonstrating that the key B-cell-determining transcription factor E2A is...

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Identifiers

PMID: 16563865
DOI: 10.1016/j.it.2006.03.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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