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Article

Single Cell Bottlenecks in the Pathogenesis of Streptococcus pneumoniae

12 Oct 2016

Abstract excerpt

Herein, we studied a virulent isolate of the leading bacterial pathogen Streptococcus pneumoniae in an infant mouse model of colonization, disease and transmission, both with and without influenza A (IAV) co-infection. To identify vulnerable points in the multiple steps involved in pneumococcal pathogenesis, this model was utilized for a comprehensive analysis of population bottlenecks. Our findings reveal that...

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PMID: 27732665
DOI: 10.1371/journal.ppat.1005887

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