Article
Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Serotype 1 in The Gambia.
The Journal of infectious diseases - 5 Dec 2017
Bricio-Moreno Laura, Ebruke Chinelo, Chaguza Chrispin, Cornick Jennifer, Kwambana-Adams Brenda, Yang Marie, Mackenzie Grant, Wren Brendan W, Everett Dean, Antonio Martin, Kadioglu Aras
Abstract excerpt
Streptococcus pneumoniae serotype 1 is one of the leading causes of invasive pneumococcal disease (IPD) in West Africa, with ST618 being the dominant cause of IPD in The Gambia. Recently however, a rare example of clonal replacement was observed, where the ST3081 clone of serotype 1 replaced the predominant ST618 clone as the main cause of IPD. In the current study, we sought to find the reasons for this unusual...
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