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Article

APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome.

The Journal of infectious diseases - 13 Sept 2022

Khalfi Pierre, Suspène Rodolphe, Caval Vincent, Thiers Valérie, Beauclair Guillaume, Marchio Agnès, Bekondi Claudine, Amougou Atsama Marie, Camengo-Police Serge Magloire, Noah Noah Dominique, Njouom Richard, Blanc Hervé, Vallet Thomas, Vignuzzi Marco, Pineau Pascal, Vartanian Jean Pierre

Abstract excerpt

Single-nucleotide polymorphism in APOBEC3C (resulting in a serine to isoleucine in position 188) is present in approximately 10% of African populations and greatly enhances restriction against human immunodeficiency virus-1 and simian immunodeficiency virus by improving dimerization and DNA processivity of the enzyme. In this study, we demonstrated in culture and in infected patients that hepatitis B virus (HBV)...

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Identifiers

PMID: 35022749
DOI: 10.1093/infdis/jiac003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome.PMID 35022749Read ↗

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