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Article

New biallelic mutations in PADI6 cause recurrent preimplantation embryonic arrest characterized by direct cleavage.

Journal of assisted reproduction and genetics - 1 Jan 2020

Zheng Wei, Chen Longbin, Dai Jing, Dai Can, Guo Jing, Lu Changfu, Gong Fei, Lu Guangxiu, Lin Ge

Abstract excerpt

PURPOSE: To investigate the pathogenesis of the recurrent preimplantation embryonic arrest characterized by direct cleavage. METHODS: Two affected individuals underwent time-lapse imaging to observe the cleavage behaviors in their final ICSI attempts. In addition, both patients were subjected to whole-exome sequencing. After the identification of possible causative genes, molecular modeling analyses were used to...

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Identifiers

PMID: 31664658
DOI: 10.1007/s10815-019-01606-7
PMCID: PMC7000584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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