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Article

TLE6 mutation causes the earliest known human embryonic lethality.

Genome biology - 5 Nov 2015

Alazami Anas M, Awad Salma M, Coskun Serdar, Al-Hassan Saad, Hijazi Hadia, Abdulwahab Firdous M, Poizat Coralie, Alkuraya Fowzan S

Abstract excerpt

BACKGROUND: Embryonic lethality is a recognized phenotypic expression of individual gene mutations in model organisms. However, identifying embryonic lethal genes in humans is challenging, especially when the phenotype is manifested at the preimplantation stage. RESULTS: In an ongoing effort to exploit the highly consanguineous nature of the Saudi population to catalog recessively acting embryonic lethal genes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26537248
DOI: 10.1186/s13059-015-0792-0
PMCID: PMC4634911

Genes

TLE6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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TLE6 mutation causes the earliest known human embryonic lethality.PMID 26537248Read ↗

A novel variant in TLE6 is associated with embryonic developmental arrest (EDA) in familial female infertility.Semantic proximity Read ↗

Novel Biallelic TLE6 Variants Induce Preimplantation Embryonic Lethality That Cannot be Rescued by IVF or ICSISemantic proximity Read ↗

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Biallelic Recessive Mutations in TLE6 and NLRP5 Cause Female Infertility Characterized by Human Early Embryonic ArrestSemantic proximity Read ↗

Expanding the genetic and phenotypic spectrum of the subcortical maternal complex genes in recurrent preimplantation embryonic arrest.Semantic proximity Read ↗

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