Article
Genome-wide association studies of chronic kidney disease: what have we learned?
Nature reviews. Nephrology - 6 Dec 2011
O'Seaghdha Conall M, Fox Caroline S
Abstract excerpt
The past 3 years have witnessed a dramatic expansion in our knowledge of the genetic determinants of estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). However, heritability estimates of eGFR indicate that we have only identified a small proportion of the total heritable contribution to the phenotypic variation. The majority of associations reported from genome-wide association studies...
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