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Article

Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture

28 Nov 2018

Abstract excerpt

Tumorigenesis depends on intricate interactions between genetically altered tumor cells and their surrounding microenvironment. While oncogenic drivers in lung squamous carcinoma (LUSC) have been described, the role of stroma in modulating tissue architecture, particularly cell polarity, remains unclear. Here, we report the establishment of a 3D coculture system of LUSC epithelial cells with cancer-associated...

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PMID: 30487219
DOI: 10.1073/pnas.1803718115

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