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Article

A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model.

Differentiation; research in biological diversity - 1 Dec 2004

Meyer Birgit, Bazzi Hisham, Zidek Vaclav, Musilova Alena, Pravenec Michal, Kurtz Theodore W, Nurnberg Peter, Christiano Angela M

Abstract excerpt

A recessive hairless mutation arose spontaneously in a congenic line of spontaneously hypertensive rats SHR.BN-(D1Mit3-Igf2)/Ipcv. The mutant rats develop generalized alopecia except for partial hair growth on their heads. Affected animals of the congenic line were crossed with LEW rats and randomly bred for several generations. A genome scan in 74 affected and 75 unaffected offspring localized the mutant gene on...

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Identifiers

PMID: 15617564
DOI: 10.1111/j.1432-0436.2004.07209007.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model.PMID 15617564Read ↗

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