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Article

DNA repair protein involved in heart and blood development.

Molecular and cellular biology - 1 Dec 2006

Wang Yi, Shupenko Craig C, Melo Luisa F, Strauss Phyllis R

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1, a key enzyme in repairing abasic sites in DNA, is an embryonic lethal in mice. We are examining its role in embryogenesis in zebra fish. Zebra fish contain two genomic copies (zfAPEX1a and zfAPEX1b) with identical coding sequences. zfAPEX1b lacks introns. Recombinant protein (ZAP1) is highly homologous with and has the same enzymatic properties as its human orthologue. ZAP1...

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Share to DNA-(Apurinic or Apyrimidinic Site) Lyase
Share to Embryo, Nonmammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

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Share to Oligonucleotides, Antisense

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Source

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Identifiers

PMID: 16966376
DOI: 10.1128/MCB.01216-06
PMCID: PMC1636828

Genes

APEX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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