Article
The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.
ACS infectious diseases - 13 Jan 2017
Singh Vinayak, Donini Stefano, Pacitto Angela, Sala Claudia, Hartkoorn Ruben C, Dhar Neeraj, Keri Gyorgy, Ascher David B, Mondésert Guillaume, Vocat Anthony, Lupien Andréanne, Sommer Raphael, Vermet Hélène, Lagrange Sophie, Buechler Joe, Warner Digby F, McKinney John D, Pato Janos, Cole Stewart T, Blundell Tom L, Rizzi Menico, Mizrahi Valerie
Abstract excerpt
VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis (Mtb), was identified by phenotypic screening of a 15344-compound library. Sequencing of a VCC234718-resistant mutant identified a Y487C substitution in the inosine monophosphate dehydrogenase, GuaB2, which was subsequently validated to be the primary molecular target of VCC234718 in Mtb. VCC234718 inhibits Mtb GuaB2 with a...
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