Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli

5 Sept 2024

Abstract excerpt

ABSTRACT Inosine 5′-monophosphate dehydrogenase (IMPDH), known as GuaB in bacteria, catalyzes the rate-limiting step in de novo guanine biosynthesis and is conserved from humans to bacteria. We developed a series of potent inhibitors that selectively target GuaB over its human homolog. Here, we show that these GuaB inhibitors are bactericidal, generate phenotypic signatures that are distinct from other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to CRISPR and Genetic Engineering
Share to Cytomegalovirus and herpesvirus research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39235234
DOI: 10.1128/jb.00102-24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coliPMID 39235234Read ↗

Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infectionSemantic proximity Read ↗

The impact of bacterial purine metabolism on antibiotic efficacySemantic proximity Read ↗

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.Semantic proximity Read ↗

Dissecting the collateral damage of antibiotics on gut microbesSemantic proximity Read ↗

The role of cyclic nucleotides in bacterial antimicrobial resistance and toleranceSemantic proximity Read ↗

Inosine reverses multidrug resistance in Gram-negative bacteria carrying mobilized RND-type efflux pump gene cluster tmexCD-toprJSemantic proximity Read ↗

Global response to antibiotic exposure uncovers a critical role for nucleotide metabolism in high-level β-lactam toleranceSemantic proximity Read ↗

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.Semantic proximity Read ↗

Deciphering the Antibacterial Mechanisms of 5-Fluorouracil in Escherichia coli through Biochemical and Transcriptomic AnalysesSemantic proximity Read ↗

A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.Semantic proximity Read ↗

Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infectionsSemantic proximity Read ↗

Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.