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Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection

29 Aug 2024

Abstract excerpt

ABSTRACT Guanine nucleotides are required for growth and viability of cells due to their structural role in DNA and RNA, and their regulatory roles in translation, signal transduction, and cell division. The natural antibiotic mycophenolic acid (MPA) targets the rate-limiting step in de novo guanine nucleotide biosynthesis executed by inosine-5´-monophosphate dehydrogenase (IMPDH). MPA is used clinically as an...

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PMID: 39207111
DOI: 10.1128/mbio.00897-24

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