Article
The solution structure of an anti-CRISPR protein.
Nature communications - 11 Oct 2016
Maxwell Karen L, Garcia Bianca, Bondy-Denomy Joseph, Bona Diane, Hidalgo-Reyes Yurima, Davidson Alan R
Abstract excerpt
Bacterial CRISPR-Cas adaptive immune systems use small guide RNAs to protect against phage infection and invasion by foreign genetic elements. We previously demonstrated that a group of Pseudomonas aeruginosa phages encode anti-CRISPR proteins that inactivate the type I-F and I-E CRISPR-Cas systems using distinct mechanisms. Here, we present the three-dimensional structure of an anti-CRISPR protein and map a...
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