Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.

BMC cancer - 10 Oct 2016

Flahaut Marjorie, Jauquier Nicolas, Chevalier Nadja, Nardou Katya, Balmas Bourloud Katia, Joseph Jean-Marc, Barras David, Widmann Christian, Gross Nicole, Renella Raffaele, Mühlethaler-Mottet Annick

Abstract excerpt

BACKGROUND: The successful targeting of neuroblastoma (NB) by associating tumor-initiating cells (TICs) is a major challenge in the development of new therapeutic strategies. The subfamily of aldehyde dehydrogenases 1 (ALDH1) isoenzymes, which comprises ALDH1A1, ALDH1A2, and ALDH1A3, is involved in the synthesis of retinoic acid, and has been identified as functional stem cell markers in diverse cancers. By...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase
Share to Aldehyde Dehydrogenase 1 Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldehyde Oxidoreductases

Share to Gene Knockout Techniques

Share to Heterografts

Share to Isoenzymes

Share to Neuroblastoma

Share to Retinal Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 27724856
DOI: 10.1186/s12885-016-2820-1
PMCID: PMC5057398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.PMID 27724856Read ↗

Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastomaSemantic proximity Read ↗

Emerging Roles of Aldehyde Dehydrogenase Isoforms in Anti-cancer Therapy ResistanceSemantic proximity Read ↗

The Significance of Aldehyde Dehydrogenase 1 in CancersSemantic proximity Read ↗

Aldehyde dehydrogenase 1A1 in stem cells and cancerSemantic proximity Read ↗

Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive NeuroblastomaSemantic proximity Read ↗

The Expanding Role of Cancer Stem Cell Marker ALDH1A3 in Cancer and BeyondSemantic proximity Read ↗

Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk NeuroblastomaSemantic proximity Read ↗

Aldehyde Dehydrogenase Activity Is a Biomarker of Primitive Normal Human Mammary Luminal CellsSemantic proximity Read ↗

Palbociclib releases the latent differentiation capacity of neuroblastoma cellsSemantic proximity Read ↗

Multiple roles of ALDH1 in health and diseaseSemantic proximity Read ↗

Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppressionSemantic proximity Read ↗

ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory MechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.