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Article

Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive Neuroblastoma

12 Dec 2013

Abstract excerpt

Neuroblastoma arises from the embryonal neural crest secondary to a block in differentiation. Long-term patient survival correlates inversely with the extent of differentiation, and treatment with retinoic acid or other prodifferentiation agents improves survival modestly. In this study, we show the histone chaperone and epigenetic regulator CHAF1A functions in maintaining the highly dedifferentiated state of...

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PMID: 24335960
DOI: 10.1158/0008-5472.can-13-1315

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