Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma

7 Jan 2015

Abstract excerpt

UNLABELLED: In neuroblastoma, MYCN genomic amplification and segmental chromosomal alterations including 1p or 11q loss of heterozygocity and/or 17q gain are associated with progression and poor clinical outcome. Segmental alterations are the strongest predictor of relapse and result from unbalanced translocations attributable to erroneous repair of chromosomal breaks. Although sequence analysis of affected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Neuroblastoma Research and Treatments
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25563294
DOI: 10.1158/1541-7786.mcr-14-0337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk NeuroblastomaPMID 25563294Read ↗

Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiationSemantic proximity Read ↗

DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastomaSemantic proximity Read ↗

Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer’s Achilles’ HeelSemantic proximity Read ↗

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteomeSemantic proximity Read ↗

DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastomaSemantic proximity Read ↗

DLG2 Impairs dsDNA Break Repair and Maintains Genome Integrity in NeuroblastomaSemantic proximity Read ↗

c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase–Activated LeukemiasSemantic proximity Read ↗

Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.Semantic proximity Read ↗

Mutational spectrum of ATRX aberrations in neuroblastoma and associated patient and tumor characteristics.Semantic proximity Read ↗

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the StageSemantic proximity Read ↗

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastomaSemantic proximity Read ↗

Neuroblastoma survivors are at increased risk for second malignancies: A report from the International Neuroblastoma Risk Group Project.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.