Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis.

Arthritis research & therapy - 4 Oct 2016

Torices Silvia, Julia Antonio, Muñoz Pedro, Varela Ignacio, Balsa Alejandro, Marsal Sara, Fernández-Nebro Antonio, Blanco Francisco, López-Hoyos Marcos, Martinez-Taboada Víctor, Fernández-Luna Jose L

Abstract excerpt

BACKGROUND: Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is as yet unknown. We aimed at identifying TLR10 variants within all coding regions of the gene in patients with RA as well as studying their functional and clinical significance. METHODS: TLR10 gene variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antirheumatic Agents
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Gene Expression Regulation

Share to High-Throughput Nucleotide Sequencing

Share to Infliximab

Share to NF-kappa B

Share to Real-Time Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 27716427
DOI: 10.1186/s13075-016-1113-z
PMCID: PMC5050569

Genes

TLR10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis.PMID 27716427Read ↗

Evaluation of Toll-like-receptor gene family variants as prognostic biomarkers in rheumatoid arthritis.Semantic proximity Read ↗

Analysis of TLR10 gene polymorphisms in patients with rheumatoid arthritis.Semantic proximity Read ↗

Polymorphisms within Genes Involved in Regulation of the NF-κB Pathway in Patients with Rheumatoid Arthritis.Semantic proximity Read ↗

Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis.Semantic proximity Read ↗

Gene discovery in rheumatoid arthritis highlights the CD40/NF-kappaB signaling pathway in disease pathogenesis.Semantic proximity Read ↗

TLR10: Insights, controversies and potential utility as a therapeutic target.Semantic proximity Read ↗

Association between the NLRP3 rs10157379 and rs10754558 genetic variants with rheumatoid arthritis activity, autoantibodies, and inflammatory biomarkersSemantic proximity Read ↗

Analysis of TNFAIP3, IRAK1, and TLR4 Gene Polymorphisms in Patients With Rheumatoid Arthritis.Semantic proximity Read ↗

Toll-like receptor polymorphisms and rheumatoid arthritis: a systematic review.Semantic proximity Read ↗

NFKB1 promoter -94 insertion/deletion ATTG polymorphism (rs28362491) is associated with severity and disease progression of rheumatoid arthritis through interleukin-6 levels modulation in Egyptian patients.Semantic proximity Read ↗

Association of Toll-like Receptor 4 Rs7873784 G/C Polymorphism with Rheumatoid Arthritis Risk in a Chinese Population.Semantic proximity Read ↗

Is there an Inflammation Role for MYD88 in Rheumatoid Arthritis?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.