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Article

Evaluation of Toll-like-receptor gene family variants as prognostic biomarkers in rheumatoid arthritis.

Immunology letters - 1 Jul 2017

Torices Silvia, Alvarez-Rodríguez Lorena, Varela Ignacio, Muñoz Pedro, Balsa Alejandro, López-Hoyos M, Martinez-Taboada Víctor, Fernández-Luna Jose L

Abstract excerpt

Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main feature is persistent joint inflammation. Toll-like receptors (TLRs) play critical roles in the activation of innate and adaptive immune responses, and influence the activity of NFκB, a key player in chronic inflammation. We aimed at investigating the association of TLR allelic variants with susceptibility and severity of RA through a...

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Source

Identifiers

PMID: 28495399
DOI: 10.1016/j.imlet.2017.04.011

Genes

TLR8
TLR1
TLR7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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