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Article

Contribution of epigenetic mechanisms to variation in cancer risk among tissues.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2017

Klutstein Michael, Moss Joshua, Kaplan Tommy, Cedar Howard

Abstract excerpt

Recently, it was suggested that tissue variation in cancer risk originates from differences in the number of stem-cell divisions underlying each tissue, leading to different mutation loads. We show that this variation is also correlated with the degree of aberrant CpG island DNA methylation in normal cells. Methylation accumulates during aging in a subset of molecules, suggesting that the epigenetic landscape...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28193856
DOI: 10.1073/pnas.1616556114
PMCID: PMC5338490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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