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Epigenetic Drift, Epigenetic Clocks and Cancer Risk

22 Apr 2016

Abstract excerpt

It is well-established that the DNA methylation landscape of normal cells undergoes a gradual modification with age, termed as 'epigenetic drift'. Here, we review the current state of knowledge of epigenetic drift and its potential role in cancer etiology. We propose a new terminology to help distinguish the different components of epigenetic drift, with the aim of clarifying the role of the epigenetic clock,...

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PMID: 27104983
DOI: 10.2217/epi-2015-0017

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