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Hotspot Exon 15 Mutations in BRAF Are Uncommon in Feline Tumours.

Veterinary and comparative oncology - 1 Sept 2024

Kuroki Kei, Hoang Christine Tran, Rogic Anita M, Rindt Hans, Simenson Angelynn, Noall Lucie G, Bryan Jeffrey N, Johnson Gayle C, Chu Shirley

Abstract excerpt

BRAF is one of multiple RAF proteins responsible for the activation of the MAPK cell signalling cascade involved in cell growth, differentiation, and survival. A hotspot BRAFV600E mutation, in exon 15, was determined to be a driver in 100% hairy cell leukaemias, 50%-60% of human melanomas, 30%-50% of human thyroid carcinomas and 10%-20% of human colorectal carcinomas. The orthologous BRAFV595E mutation was seen...

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PMID: 39015955
DOI: 10.1111/vco.12997

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