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Article

Effect of growth hormone and IgG aggregates on dendritic cells activation and T-cells polarization.

Immunology and cell biology - 1 Mar 2017

Gallais Yann, Szely Natacha, Legrand François-Xavier, Leroy Arnaud, Pallardy Marc, Turbica Isabelle

Abstract excerpt

Patients treated with therapeutic biological products (BP) frequently develop anti-drug antibodies (ADA) with potential neutralizing capacities leading to loss of clinical response or serious side effects. BP aggregates have been suggested to promote immunogenicity, thus enhancing ADA production. Dendritic cells (DC) are key effectors in T-cell and B-cell fates, and the subsequent generation of immunogenicity....

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Source

Identifiers

PMID: 27713394
DOI: 10.1038/icb.2016.100

Genes

ADA
CXCL10
CCL2
CCL3
CCL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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