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Article

Cost-benefit tradeoffs in engineered lac operons.

Science (New York, N.Y.) - 18 May 2012

Eames Matt, Kortemme Tanja

Abstract excerpt

Cells must balance the cost and benefit of protein expression to optimize organismal fitness. The lac operon of the bacterium Escherichia coli has been a model for quantifying the physiological impact of costly protein production and for elucidating the resulting regulatory mechanisms. We report quantitative fitness measurements in 27 redesigned operons that suggested that protein production is not the primary...

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PMID: 22605776
DOI: 10.1126/science.1219083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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