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Article

Targeted Genome Editing via CRISPR in the Pathogen Cryptococcus neoformans.

PloS one - 1 Jan 2016

Arras Samantha D M, Chua Sheena M H, Wizrah Maha S I, Faint Joshua A, Yap Amy S, Fraser James A

Abstract excerpt

Low rates of homologous integration have hindered molecular genetic studies in Cryptococcus neoformans over the past 20 years, and new tools that facilitate genome manipulation in this important pathogen are greatly needed. To this end, we have investigated the use of a Class 2 CRISPR system in C. neoformans (formerly C. neoformans var. grubii). We first expressed a derivative of the Streptococcus pyogenes Cas9...

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Identifiers

PMID: 27711143
DOI: 10.1371/journal.pone.0164322
PMCID: PMC5053423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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