LRRK2 variation and dementia with Lewy bodies.

doi:10.1016/j.parkreldis.2016.07.015

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Article

LRRK2 variation and dementia with Lewy bodies.

Parkinsonism & related disorders - 1 Oct 2016

Heckman Michael G, Soto-Ortolaza Alexandra I, Contreras Monica Y Sanchez, Murray Melissa E, Pedraza Otto, Diehl Nancy N, Walton Ronald, Labbé Catherine, Lorenzo-Betancor Oswaldo, Uitti Ryan J, van Gerpen Jay, Ertekin-Taner Nilüfer, Smith Glenn E, Kantarci Kejal, Savica Rodolfo, Jones David T, Graff-Radford Jonathan, Knopman David S, Lowe Val J, Jack Clifford R, Petersen Ronald C, Parisi Joseph E, Rademakers Rosa, Wszolek Zbigniew K, Graff-Radford Neill R, Ferman Tanis J, Dickson Dennis W, Boeve Bradley F, Ross Owen A

Abstract excerpt

INTRODUCTION: The leucine-rich repeat kinase 2 (LRRK2) gene contains several variants that cause Parkinson's disease (PD) and others that modify PD risk. However, little is known about the role of LRRK2 in dementia with Lewy bodies (DLB). Aims of this study were to screen DLB patients for pathogenic LRRK2 variants and to evaluate associations between common LRRK2 variants and risk of DLB. METHODS: 417 clinical...

Topics

Aged
Aged, 80 and over
Brain
Female
Genetic Association Studies
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Lewy Body Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Logistic Models

Male

Middle Aged

Mutation

Retrospective Studies

alpha-Synuclein

Source

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Identifiers

PMID: 27521182
DOI: 10.1016/j.parkreldis.2016.07.015
PMCID: PMC5048558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27521182-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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